Diabetic Retinopathy (DR) is a leading cause of vision loss in the world, and early DR detection is necessary to prevent vision loss and support an appropriate treatment. In this work, we leverage interactive machine learning and introduce a joint learning framework, termed DRG-Net, to effectively learn both disease grading and multi-lesion segmentation. Our DRG-Net consists of two modules: (i) DRG-AI-System to classify DR Grading, localize lesion areas, and provide visual explanations; (ii) DRG-Expert-Interaction to receive feedback from user-expert and improve the DRG-AI-System. To deal with sparse data, we utilize transfer learning mechanisms to extract invariant feature representations by using Wasserstein distance and adversarial learning-based entropy minimization. Besides, we propose a novel attention strategy at both low- and high-level features to automatically select the most significant lesion information and provide explainable properties. In terms of human interaction, we further develop DRG-Net as a tool that enables expert users to correct the system's predictions, which may then be used to update the system as a whole. Moreover, thanks to the attention mechanism and loss functions constraint between lesion features and classification features, our approach can be robust given a certain level of noise in the feedback of users. We have benchmarked DRG-Net on the two largest DR datasets, i.e., IDRID and FGADR, and compared it to various state-of-the-art deep learning networks. In addition to outperforming other SOTA approaches, DRG-Net is effectively updated using user feedback, even in a weakly-supervised manner.

Research has shown that climate change creates warmer temperatures and drier conditions, leading to longer wildfire seasons and increased wildfire risks in the United States. These factors have in turn led to increases in the frequency, extent, and severity of wildfires in recent years. Given the danger posed by wildland fires to people, property, wildlife, and the environment, there is an urgency to provide tools for effective wildfire management. Early detection of wildfires is essential to minimizing potentially catastrophic destruction. In this paper, we present our work on integrating multiple data sources in SmokeyNet, a deep learning model using spatio-temporal information to detect smoke from wildland fires. Camera image data is integrated with weather sensor measurements and processed by SmokeyNet to create a multimodal wildland fire smoke detection system. We present our results comparing performance in terms of both accuracy and time-to-detection for multimodal data vs. a single data source. With a time-to-detection of only a few minutes, SmokeyNet can serve as an automated early notification system, providing a useful tool in the fight against destructive wildfires.

The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

Collecting large-scale medical datasets with fully annotated samples for training of deep networks is prohibitively expensive, especially for 3D volume data. Recent breakthroughs in self-supervised learning (SSL) offer the ability to overcome the lack of labeled training samples by learning feature representations from unlabeled data. However, most current SSL techniques in the medical field have been designed for either 2D images or 3D volumes. In practice, this restricts the capability to fully leverage unlabeled data from numerous sources, which may include both 2D and 3D data. Additionally, the use of these pre-trained networks is constrained to downstream tasks with compatible data dimensions. In this paper, we propose a novel framework for unsupervised joint learning on 2D and 3D data modalities. Given a set of 2D images or 2D slices extracted from 3D volumes, we construct an SSL task based on a 2D contrastive clustering problem for distinct classes. The 3D volumes are exploited by computing vectored embedding at each slice and then assembling a holistic feature through deformable self-attention mechanisms in Transformer, allowing incorporating long-range dependencies between slices inside 3D volumes. These holistic features are further utilized to define a novel 3D clustering agreement-based SSL task and masking embedding prediction inspired by pre-trained language models. Experiments on downstream tasks, such as 3D brain segmentation, lung nodule detection, 3D heart structures segmentation, and abnormal chest X-ray detection, demonstrate the effectiveness of our joint 2D and 3D SSL approach. We improve plain 2D Deep-ClusterV2 and SwAV by a significant margin and also surpass various modern 2D and 3D SSL approaches.

This work demonstrates the ability to produce readily interpretable statistical metrics for model fit, fixed effects covariance coefficients, and prediction confidence. Importantly, this work compares 4 suitable and commonly applied epistemic UQ approaches, BNN, SWAG, MC dropout, and ensemble approaches in their ability to calculate these statistical metrics for the ARMED MEDL models. In our experiment for AD prognosis, not only do the UQ methods provide these benefits, but several UQ methods maintain the high performance of the original ARMED method, some even provide a modest (but not statistically significant) performance improvement. The ensemble models, especially the ensemble method with a 90% subsampling, performed well across all metrics we tested with (1) high performance that was comparable to the non-UQ ARMED model, (2) properly deweights the confounds probes and assigns them statistically insignificant p-values, (3) attains relatively high calibration of the output prediction confidence. Based on the results, the ensemble approaches, especially with a subsampling of 90%, provided the best all-round performance for prediction and uncertainty estimation, and achieved our goals to provide statistical significance for model fit, statistical significance covariate coefficients, and confidence in prediction, while maintaining the baseline performance of MEDL using ARMED

Large language models (LLMs) have been shown to be able to perform new tasks based on a few demonstrations or natural language instructions. While these capabilities have led to widespread adoption, most LLMs are developed by resource-rich organizations and are frequently kept from the public. As a step towards democratizing this powerful technology, we present BLOOM, a 176B-parameter open-access language model designed and built thanks to a collaboration of hundreds of researchers. BLOOM is a decoder-only Transformer language model that was trained on the ROOTS corpus, a dataset comprising hundreds of sources in 46 natural and 13 programming languages (59 in total). We find that BLOOM achieves competitive performance on a wide variety of benchmarks, with stronger results after undergoing multitask prompted finetuning. To facilitate future research and applications using LLMs, we publicly release our models and code under the Responsible AI License.

While feature association to a global map has significant benefits, to keep the computations from growing exponentially, most lidar-based odometry and mapping methods opt to associate features with local maps at one voxel scale. Taking advantage of the fact that surfels (surface elements) at different voxel scales can be organized in a tree-like structure, we propose an octree-based global map of multi-scale surfels that can be updated incrementally. This alleviates the need for recalculating, for example, a k-d tree of the whole map repeatedly. The system can also take input from a single or a number of sensors, reinforcing the robustness in degenerate cases. We also propose a point-to-surfel (PTS) association scheme, continuous-time optimization on PTS and IMU preintegration factors, along with loop closure and bundle adjustment, making a complete framework for Lidar-Inertial continuous-time odometry and mapping. Experiments on public and in-house datasets demonstrate the advantages of our system compared to other state-of-the-art methods. To benefit the community, we release the source code and dataset at https://github.com/brytsknguyen/slict.

由不同类型的节点和边缘组成的学习异质图增强了均匀图技术的结果。这样的图形的一个有趣示例是代表可能的软件代码执行流的控制流图。由于此类图代表了代码的更多语义信息，因此为这些图形开发技术和工具可能对检测软件中的漏洞的可靠性非常有益。但是，现有的异质图技术仍然不足以处理复杂的图形，在处理复杂的图形中，不同类型的节点和边缘数量较大且可变。本文集中于以太坊智能合约作为由构建在控制流图和包含不同类型的节点和链接的呼叫图的异质合同图表示的软件代码样本。我们提出了曼多（Mando），这是一种新的异质图表示，以学习这种异质合同图的结构。 Mando提取自定义的Metapaths，该Metapaths在不同类型的节点及其邻居之间建立了关系连接。此外，它开发了一个多米达异构图注意网络，以学习不同类型的节点及其在异质合同图中的多层嵌入，可以更准确地捕获智能合约的代码语义，并便利两者。 - 水平和粗粒合同级别的漏洞检测。我们对大型智能合同数据集的广泛评估表明，曼多（Mando）在粗粒合同水平上改善了其他技术的脆弱性检测结果。更重要的是，它是第一种基于学习的方法，能够在细粒度的线条层面上识别漏洞，并在F1分数方面将基于代码分析的传统漏洞检测方法显着提高了11.35％至70.81％。

深度估计是在机器人手术和腹腔镜成像系统中进行图像引导干预的关键步骤。由于对于腹腔镜图像数据很难获得人均深度地面真相，因此很少将监督深度估计应用于手术应用。作为替代方案，已经引入了仅使用同步的立体图像对来训练深度估计器。但是，最近的工作集中在2D中的左右一致性上，而忽略了现实世界坐标中对象的宝贵固有3D信息，这意味着左右3D几何结构一致性尚未得到充分利用。为了克服这一限制，我们提出了M3Depth，这是一种自我监督的深度估计器，以利用3D几何结构信息隐藏在立体声对中，同时保持单眼推理。该方法还消除了在至少一个立体声图像中通过掩码看不见的边界区域的影响，以增强重叠区域中的左图和右图像之间的对应关系。密集实验表明，我们的方法在公共数据集和新获取的数据集上的以前的自我监督方法都大大优先，这表明在不同的样品和腹腔镜上都有良好的概括。

大型语言模型已经证明了能够在自然语言和编程语言文本上进行条件和生成的能力。这样的模型打开了多语言代码生成的可能性：代码生成模型是否可以将知识从一种语言推广到另一种语言？尽管当代代码生成模型可以生成语义上正确的Python代码，但对它们使用其他语言的能力知之甚少。我们通过提出Multipl-E来促进该主题的探索，这是自然语言到代码生成的第一个多语言平行基准。 Multipl-E扩展了HumaneVal基准（Chen等，2021），以支持另外18种编程语言，涵盖了一系列编程范式和受欢迎程度。我们在Multipl-E：Codex和Incoder上评估了两个最先进的代码生成模型。我们发现，在几种语言上，法典匹配，甚至超过了其在Python上的性能。在多型E中表示的编程语言范围使我们能够探索语言频率和语言功能对模型性能的影响。最后，将代码生成基准分配给新编程语言的多重方法既可扩展又可扩展。我们描述了一种通用方法，可以轻松地增加对新基准和语言的支持。